Red Blood Cell Deformability
We observed from various measures of deformability that the RBCs isolated from ME / CFS patients were significantly stiffer than those from healthy controls. Our observations suggest that RBC transport through microcapillaries may explain, at least in part, the ME / CFS phenotype, and promises to be a novel first-pass diagnostic test.
Since it potentially could be a biomarker for the diagnosis of ME/CFS, we are proceeding to design new devices that will make a clear distinction between patients and healthy controls. These devices will be hand-held and easy to use by doctors in their offices, or in clinical testing labs.