Metabolic Trap Hypothesis
Dr. Robert Phair has recently published a paper detailing his “metabolic trap” hypothesis underlying ME / CFS, a theory that combines engineering and physiology put together by a man adept in both fields.
The IDO1 and IDO2 genes are named so similarly because they each encode for enzymes that transform an essential amino acid (tryptophan) into an important regulator of the immune system (kynurenine). If for any reason the tryptophan levels in a cell rise too high, then IDO1 will stop making kynurenine and tryptophan levels will remain high. This is the IDO metabolic trap.