ME/CFS is a devastating disorder with unclear aetiology and no clear diagnostic biomarker available. This study support the existence of a general pattern of increased antibody levels to adrenergic and muscarinic receptors within the ME/CFS patient group.
No evidence for intrathecal antibody production was found in cerebrospinal fluid (CSF). The role of increased autoantibodies in the pathogenesis of ME/CFS is still uncertain and further research is needed to evaluate their clinical significance.
Preliminary studies using immunoadsorption and/or plasmapheresis to remove the antibodies show positive effects in at least a subpopulation of ME/CFS patients.